Action Potential Timing Determines Dendritic Calcium during Striatal Up-States
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چکیده
منابع مشابه
Action potential timing determines dendritic calcium during striatal up-states.
Up-states represent a key feature of synaptic integration in cortex and striatum that involves activation of many synaptic inputs. In the striatum, the sparse firing and tight control of action potential timing is in contrast to the large intracellular membrane potential depolarizations observed during the up-state. One hallmark of striatal spiny projection neurons is the delay to action potent...
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Striatal spiny projection neurons control basal ganglia outputs via action potential bursts conveyed to the globus pallidus and substantia nigra. Accordingly, burst activity in these neurons contributes importantly to basal ganglia function and dysfunction. These bursts are driven by multiple corticostriatal inputs that depolarize spiny projection neurons from their resting potential of approxi...
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24 The striatum of the basal ganglia demonstrates distinctive upstate and downstate 25 membrane potential oscillations during slow wave sleep and under anesthetic. The upstates 26 generate calcium transients in the dendrites and the amplitude of these calcium transients 27 depends strongly on the timing of the action potential (AP) within the upstate. Calcium is 28 essential for synaptic plasti...
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Up states are prolonged membrane potential depolarizations critical for synaptic integration and action potential generation in cortical and striatal neurons. They commonly result from numerous concurrent synaptic inputs, whereas neurons reside in a down state when synaptic inputs are few. By quantifying the composition, frequency, and amplitude of synaptic inputs for both states, we provide im...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2004
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4475-03.2004